How to Manage Estrogen on TRT
A clear, step-by-step guide to help you manage estrogen on trt. This guide is specific to Anastrozole (Arimidex).
Step-by-Step Guide
Get baseline estradiol (E2) tested before starting TRT
Recheck estradiol 6-8 weeks after starting TRT or any dose change
If E2 is elevated (typically above 50 pg/mL) with symptoms, discuss anastrozole with your provider
Start anastrozole at a low dose (0.25mg twice weekly) and titrate based on labs
Monitor for signs of crashed estrogen: joint pain, fatigue, low mood, dry skin, low libido
Recheck E2 4-6 weeks after starting or adjusting AI dose
Consider lifestyle factors: reducing body fat decreases aromatization naturally
Some men manage E2 through more frequent testosterone injections rather than AI use
About Anastrozole
Anastrozole (Arimidex) is a Aromatase inhibitor (AI) administered as a Oral pill taken 1-3 times per week. The standard dosage options are 0.25mg 2x/week, 0.5mg 2x/week, 1mg 2x/week.
Compounded anastrozole is available through TRT clinics at $10-30/mo, compared to the brand-name price of $20-60/mo.
Important Reminders
- Always follow your healthcare provider's specific instructions
- Testosterone is a controlled substance requiring a prescription and medical oversight
- Get regular bloodwork every 3-6 months to monitor your levels
- Report any unexpected symptoms to your provider promptly