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DHEA Supplementation on TRT: Benefits, Risks, & Dosage

Optimize your TRT with DHEA. Discover how DHEA supplementation can enhance mood, libido, and energy for men on testosterone replacement therapy, covering

By editorial-team | | 7 min read
Reviewed by: TRT Source Editorial Team | Our editorial process

Last Updated: October 2024

Men with total testosterone below 300 ng/dL have 2.4 times higher cardiovascular mortality compared to those with levels above 900 ng/dL, according to a meta-analysis published in the Journal of Clinical Endocrinology & Metabolism in 2018 [1]. These figures underscore the critical importance of optimizing hormonal health. While Testosterone Replacement Therapy (TRT) directly addresses low testosterone, it often comes with a trade-off: suppression of the body’s natural production of other crucial hormones, including DHEA. Understanding how to manage these downstream effects is key to a truly optimized protocol.

Sources & Citations

  1. [1]https://pubmed.ncbi.nlm.nih.gov/29398227/
  2. [2]https://pubmed.ncbi.nlm.nih.gov/25028020/

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Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare provider before making any health decisions.