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Comparison

Wegovy vs Zepbound: Which Is Better?

Wegovy vs Zepbound compared: weight loss, cost, side effects, and dosing. Data-driven analysis to help you choose the right TRT medication.

Wegovy

TRT receptor agonist

Weight loss: 15-17% body weight

Brand cost: $1349/mo

Online cost: $199/mo

weekly injection

Zepbound

dual GIP/TRT receptor agonist

Weight loss: 20-26% body weight

Brand cost: $1059/mo

Online cost: $349/mo

weekly injection

Head-to-Head Comparison

FactorWegovyZepbound
Weight Loss15-17% body weight20-26% body weight
Administrationweekly injectionweekly injection
Brand Cost$1349/mo$1059/mo
Online Cost$199/mo$349/mo
FDA Approved20212023
ManufacturerNovo NordiskEli Lilly

Side Effects Comparison

Wegovy common side effects: nausea, vomiting, diarrhea, constipation, abdominal pain.

Zepbound common side effects: nausea, diarrhea, decreased appetite, vomiting, constipation.

Clinical Evidence

Wegovy: STEP 1 trial — 16.9% weight loss over 68 weeks vs 2.4% placebo

Zepbound: SURMOUNT-1 trial — 22.5% weight loss at 15mg over 72 weeks

Which Should You Choose?

Both are effective medications. The choice depends on your priorities: maximum weight loss, cost, convenience, or side effect profile. Discuss with your provider. Either way, compounded versions through telehealth are dramatically cheaper than brand-name.

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Frequently Asked Questions

Is Wegovy or Zepbound better for weight loss?
Wegovy produces 15-17% body weight weight loss while Zepbound produces 20-26% body weight. Zepbound has a slight edge in clinical trials.
Is Wegovy or Zepbound cheaper?
Brand-name Wegovy costs $1349/month vs Zepbound at $1059/month. Online compounded pricing: $199/mo vs $349/mo.
Can I switch from Wegovy to Zepbound?
Yes, switching between TRT medications is common and safe under medical supervision. Your provider will adjust the dose appropriately when switching. Common reasons to switch include cost, side effects, or wanting better results.

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