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Comparison

Ozempic vs Contrave: Which Is Better?

Ozempic vs Contrave compared: weight loss, cost, side effects, and dosing. Data-driven analysis to help you choose the right TRT medication.

Ozempic

TRT receptor agonist

Weight loss: 15-17% body weight

Brand cost: $1349/mo

Online cost: $199/mo

weekly injection

Contrave

opioid antagonist + aminoketone antidepressant combination

Weight loss: 5-6% body weight

Brand cost: $320/mo

Online cost: $99/mo

oral tablet daily

Head-to-Head Comparison

FactorOzempicContrave
Weight Loss15-17% body weight5-6% body weight
Administrationweekly injectionoral tablet daily
Brand Cost$1349/mo$320/mo
Online Cost$199/mo$99/mo
FDA Approved20212014
ManufacturerNovo NordiskCurrax Pharmaceuticals

Side Effects Comparison

Ozempic common side effects: nausea, vomiting, diarrhea, constipation, abdominal pain.

Contrave common side effects: nausea, constipation, headache, vomiting, dizziness, insomnia.

Clinical Evidence

Ozempic: STEP 1 trial — 16.9% weight loss over 68 weeks vs 2.4% placebo

Contrave: COR-I trial — 6.1% weight loss over 56 weeks

Which Should You Choose?

Both are effective medications. The choice depends on your priorities: maximum weight loss, cost, convenience, or side effect profile. Discuss with your provider. Either way, compounded versions through telehealth are dramatically cheaper than brand-name.

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Frequently Asked Questions

Is Ozempic or Contrave better for weight loss?
Ozempic produces 15-17% body weight weight loss while Contrave produces 5-6% body weight. Contrave has a slight edge in clinical trials.
Is Ozempic or Contrave cheaper?
Brand-name Ozempic costs $1349/month vs Contrave at $320/month. Online compounded pricing: $199/mo vs $99/mo.
Can I switch from Ozempic to Contrave?
Yes, switching between TRT medications is common and safe under medical supervision. Your provider will adjust the dose appropriately when switching. Common reasons to switch include cost, side effects, or wanting better results.

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