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Comparison

Mounjaro vs Zepbound: Which Is Better?

Mounjaro vs Zepbound compared: weight loss, cost, side effects, and dosing. Data-driven analysis to help you choose the right TRT medication.

Mounjaro

dual GIP/TRT receptor agonist

Weight loss: 20-26% body weight

Brand cost: $1059/mo

Online cost: $349/mo

weekly injection

Zepbound

dual GIP/TRT receptor agonist

Weight loss: 20-26% body weight

Brand cost: $1059/mo

Online cost: $349/mo

weekly injection

Head-to-Head Comparison

FactorMounjaroZepbound
Weight Loss20-26% body weight20-26% body weight
Administrationweekly injectionweekly injection
Brand Cost$1059/mo$1059/mo
Online Cost$349/mo$349/mo
FDA Approved20232023
ManufacturerEli LillyEli Lilly

Side Effects Comparison

Mounjaro common side effects: nausea, diarrhea, decreased appetite, vomiting, constipation.

Zepbound common side effects: nausea, diarrhea, decreased appetite, vomiting, constipation.

Clinical Evidence

Mounjaro: SURMOUNT-1 trial — 22.5% weight loss at 15mg over 72 weeks

Zepbound: SURMOUNT-1 trial — 22.5% weight loss at 15mg over 72 weeks

Which Should You Choose?

Both are effective medications. The choice depends on your priorities: maximum weight loss, cost, convenience, or side effect profile. Discuss with your provider. Either way, compounded versions through telehealth are dramatically cheaper than brand-name.

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Frequently Asked Questions

Is Mounjaro or Zepbound better for weight loss?
Mounjaro produces 20-26% body weight weight loss while Zepbound produces 20-26% body weight. Both show similar results.
Is Mounjaro or Zepbound cheaper?
Brand-name Mounjaro costs $1059/month vs Zepbound at $1059/month. Online compounded pricing: $349/mo vs $349/mo.
Can I switch from Mounjaro to Zepbound?
Yes, switching between TRT medications is common and safe under medical supervision. Your provider will adjust the dose appropriately when switching. Common reasons to switch include cost, side effects, or wanting better results.

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